L–Citrulline is an amino acid that has been found to play an important role in nitric oxide (NO) metabolism and regulation. L-Citrulline is converted to L-Arginine in the body, leading to increases in both L-Arginine and nitric oxide. Increased production of nitric oxide promotes vascular dilation, which helps support normal oxygen and blood circulation.
NOTHING COMES CLOSE
PHARMACOKINETIC ADVANTAGES OF L-CITRULLINE
The pharmacokinetic advantage of L-Citrulline is that it is not subject to any elimination by the liver prior to entering the bloodstream. Conversely, L-Arginine is subject to extensive elimination by the gut wall and liver. The majority of L-Citrulline is converted to L-Arginine in the kidney. (1) Once in circulation, L-Arginine is readily converted into L-Citrulline and nitric oxide, which in turn serves as an L-Arginine precursor (see figure below).
CONVERSION FROM L-ARGININE TO L-CITRULLINE
ABSORPTION OF L-ARGININE & L-CITRULLINE
*Citrulline ingestion enables effective supply of arginine.
ROLES OF CITRULLINE IN THE BODY
- Converts to arginine and nitric oxide
- Supports nutrient delivery via vascular blood flow
HOW DOES PURE L-CITRULLINE COMPARE TO L-CITRULLINE MALATE?
L-Citrulline Malate is mixed 1:1 (Malic Acid + L-Citrulline). Basically, the L-Citrulline is cut in half! Most brands use L-Citrulline Malate 1:1 ratio due to cost (cheap!) – about 50% less per kilogram than Pure L-Citrulline.